| Filing Date | Insider | Type | 10b5-1 | Net Shares | Ownership change | Avg. Price | Value | Filing |
|---|---|---|---|---|---|---|---|---|
| 2026-02-04 | Quinn William P. President, CEO and CFO | Purchase | +125 | +5.71%2,313 | $4.61 | $576 | View SEC filing | |
| 2026-02-04 | Nemec Sarah Senior VP, Finance and PAO | Purchase | +125 | +9.69%1,415 | $4.61 | $576 | View SEC filing | |
| 2025-10-24 | Nemec Sarah Senior VP, Finance and PAO | Purchase | +125 | +15.28%943 | $5.49 | $687 | View SEC filing | |
| 2025-10-24 | Quinn William P. President, CEO and CFO | Purchase | +125 | +6.06%2,188 | $5.49 | $687 | View SEC filing | |
| 2025-05-05 | Nemec Sarah Senior VP, Finance and PAO | Purchase | +5,000 | +46.38%16,633 | $0.57 | $2,835 | View SEC filing | |
| 2025-05-05 | Quinn William P. President, CEO and CFO | Purchase | +5,000 | +13.78%41,272 | $0.57 | $2,835 | View SEC filing | |
| 2023-12-13 | Quinn William P. Chief Financial Officer | Purchase | +11,829 | +48.39%36,272 | $0.95 | $11,241 | View SEC filing | |
| 2023-12-01 | ENGLEMAN EDGAR Director | Sale | -148,884 | -6.70%2,073,005 | $0.87 | $128,993 | View SEC filing | |
| 2023-11-22 | Vivo Capital Fund VIII, L.P. 10% Owner | Sale | -3,400 | -0.15%2,333,551 | $0.90 | $3,060 | View SEC filing | |
| 2023-11-22 | ENGLEMAN EDGAR Director | Sale | -1,943 | -0.09%2,221,889 | $0.90 | $1,751 | View SEC filing | |
| 2023-11-20 | Vivo Capital Fund VIII, L.P. 10% Owner | Sale | -86,054 | -1.35%6,308,110 | $0.93 | $79,933 | View SEC filing | |
| 2023-11-20 | ENGLEMAN EDGAR Director | Sale | -49,173 | -2.16%2,223,832 | $0.93 | $45,675 | View SEC filing | |
| 2022-07-15 | Novo Holdings A/S 10% Owner | Sale | -800,000 | -17.76%3,703,991 | $2.00 | $1,600,000 | View SEC filing | |
| 2022-02-01 | Perez Edith A. Chief Medical Officer | Purchase | +1,328 | +100.00%1,328 | $12.93 | $17,175 | View SEC filing | |
| 2021-12-09 | Quinn William P. Chief Financial Officer | Purchase | +6,256 | +45.01%20,154 | $7.04 | $44,067 | View SEC filing | |
| 2021-02-11 | Novo Holdings A/S 10% Owner | Purchase | +400,000 | +9.75%4,503,991 | $20.00 | $8,000,000 | View SEC filing | |
| 2021-02-09 | Vivo Capital Fund VIII, L.P. 10% Owner | Mixed | +349,774 | +9.93%3,871,291 | $20.00 | $7,004,520 | View SEC filing | |
| 2021-02-09 | LAPORTE KATHLEEN Director | Purchase | +1,200 | +100.00%1,200 | $20.00 | $24,000 | View SEC filing | |
| 2021-02-09 | SHAH MAHENDRA Director | Sale | -62 | -0.00%1,448,286 | $20.00 | $1,240 | View SEC filing | |
| 2021-02-09 | HEALY JAMES Director | Purchase | +450,000 | +19.53%2,754,437 | $20.00 | $9,000,000 | View SEC filing | |
| 2021-02-09 | Khanna Ashish Siri Ram Director | Purchase | +2,200 | +100.00%2,200 | $20.00 | $44,000 | View SEC filing | |
| 2021-02-09 | ENGLEMAN EDGAR Director, 10% Owner | Mixed | +199,836 | +9.64%2,273,005 | $20.00 | $4,003,280 | View SEC filing | |
| 2021-02-09 | Quinn William P. Chief Financial Officer | Purchase | +1,200 | +9.45%13,898 | $20.00 | $24,000 | View SEC filing | |
| 2021-02-09 | Schatzman Randall C Chief Executive Officer | Purchase | +1,500 | +100.00%1,500 | $20.00 | $30,000 | View SEC filing | |
| 2021-02-09 | POWELL MICHAEL 10% Owner | Purchase | +450,000 | +19.53%2,754,437 | $20.00 | $9,000,000 | View SEC filing |
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