| Filing Date | Insider | Type | 10b5-1 | Net Shares | Ownership change | Avg. Price | Value | Filing |
|---|---|---|---|---|---|---|---|---|
| 2026-03-31 | Fairmount Funds Management LLC Director | Sale | -7,000,000 | -55.98%5,503,418 | $34.66 | $242,620,000 | View SEC filing | |
| 2026-01-22 | Fairmount Funds Management LLC Director | Sale | -3,500,000 | -38.87%5,503,418 | $36.40 | $127,400,000 | View SEC filing | |
| 2025-12-30 | Kearns Evan Chief Legal Officer | Sale | -65,000 | -37.27%109,398 | $38.70 | $2,515,500 | View SEC filing | |
| 2025-12-30 | Green John L. Chief Financial Officer | Sale | -77,000 | -36.87%131,834 | $38.68 | $2,978,360 | View SEC filing | |
| 2025-12-30 | Sachs Jessica Chief Medical Officer | Sale | -82,642 | -38.16%133,938 | $38.70 | $3,198,245 | View SEC filing | |
| 2025-12-30 | Robinson John Edward Chief Scientific Officer | Sale | -90,000 | -39.13%140,002 | $38.74 | $3,486,600 | View SEC filing | |
| 2025-07-14 | Fairmount Funds Management LLC Director | Purchase | +2,777,777 | +44.62%9,003,418 | $9.00 | $24,999,993 | View SEC filing | |
| 2025-01-15 | Pinnow Cole Chief Commercial Officer | Purchase | +43,750 | +2085.32%45,848 | $7.60 | $332,413 | View SEC filing | |
| 2023-06-13 | Fairmount Funds Management LLC 10% Owner, Other | Purchase | +800,000 | +32.36%3,272,124 | $12.00 | $9,600,000 | View SEC filing | |
| 2022-06-21 | Fairmount Funds Management LLC 10% Owner, Other | Purchase | +1,200,000 | +94.33%2,472,124 | $8.25 | $9,900,000 | View SEC filing | |
| 2021-04-28 | Green John L. Chief Financial Officer | Sale | -17,813 | -82.26%3,841 | $8.86 | $157,823 | View SEC filing | |
| 2020-10-08 | CAMPANA DARIO 10% Owner | Sale | -2,000,000 | -39.25%3,095,114 | $0.39 | $788,383 | View SEC filing | |
| 2020-08-18 | VHCP Management II, LLC 10% Owner | Purchase | +451,000 | +11.55%4,355,273 | $2.52 | $1,137,120 | View SEC filing | |
| 2020-07-13 | Fairmount Funds Management LLC 10% Owner | Purchase | +22,727,000 | +50.86%67,414,000 | $0.88 | $19,999,760 | View SEC filing | |
| 2019-03-26 | Ettenberg Seth Chief Scientific Officer | Sale | -11,485 | -100.00%0 | $4.12 | $47,334 | View SEC filing | |
| 2019-02-26 | Ettenberg Seth Chief Scientific Officer | Sale | -11,485 | -100.00%0 | $4.25 | $48,853 | View SEC filing | |
| 2018-12-28 | Ettenberg Seth Chief Scientific Officer | Sale | -11,485 | -100.00%0 | $4.05 | $46,487 | View SEC filing | |
| 2018-11-26 | Ettenberg Seth Chief Scientific Officer | Sale | -11,485 | -100.00%0 | $7.00 | $80,444 | View SEC filing | |
| 2018-10-29 | Ettenberg Seth Chief Scientific Officer | Sale | -11,485 | -100.00%0 | $8.46 | $97,201 | View SEC filing | |
| 2018-09-26 | Ettenberg Seth Chief Scientific Officer | Sale | -11,485 | -100.00%0 | $12.47 | $143,181 | View SEC filing | |
| 2018-04-05 | FMR LLC Other | Purchase | +94,052 | +26.27%452,115 | $12.00 | $1,128,624 | View SEC filing | |
| 2018-04-03 | Ratcliffe Liam Director | Purchase | +550,000 | +44.16%897,773 | $12.00 | $6,600,000 | View SEC filing | |
| 2018-04-03 | Atlas Venture Associates IX, LLC 10% Owner | Purchase | +94,052 | +2.88%3,361,535 | $12.00 | $1,128,624 | View SEC filing | |
| 2018-04-03 | Booth Bruce Director | Purchase | +94,052 | +2.88%3,361,535 | $12.00 | $1,128,624 | View SEC filing |
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