| Filing Date | Insider | Type | 10b5-1 | Net Shares | Ownership change | Avg. Price | Value | Filing |
|---|---|---|---|---|---|---|---|---|
| 2026-03-02 | DEERFIELD MANAGEMENT COMPANY, L.P. Director, 10% Owner, Other | Purchase | +5,000,000 | +16.34%35,606,974 | $5.00 | $25,000,000 | View SEC filing | |
| 2026-03-02 | Hamilton Thomas Edward Director | Purchase | +100,000 | +17.71%664,798 | $5.00 | $500,000 | View SEC filing | |
| 2026-03-02 | THOMAS FRANK E Director | Purchase | +5,000 | +250.00%7,000 | $5.00 | $25,000 | View SEC filing | |
| 2026-03-02 | SHERMAN JEFFREY W Director | Purchase | +5,000 | +100.00%5,000 | $5.00 | $25,000 | View SEC filing | |
| 2025-08-04 | DEERFIELD MANAGEMENT COMPANY, L.P. Director, 10% Owner, Other | Purchase | +9,375,000 | +55.07%26,398,992 | $3.20 | $30,000,000 | View SEC filing | |
| 2024-05-31 | Hamilton Thomas Edward Director | Purchase | +57,208 | +11.27%564,798 | $8.74 | $499,998 | View SEC filing | |
| 2024-02-16 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) Director, 10% Owner, Other | Purchase | +4,290,617 | +35.11%16,510,777 | $8.74 | $37,499,993 | View SEC filing | |
| 2024-02-15 | THOMAS FRANK E Director | Purchase | +2,000 | +100.00%2,000 | $11.00 | $22,000 | View SEC filing | |
| 2023-12-08 | Shankar Gopi Chief Development Officer | Purchase | +5,000 | +100.00%5,000 | $3.73 | $18,662 | View SEC filing | |
| 2023-05-18 | Celano Michael Chief Financial Officer | Purchase | +5,000 | +4.64%112,746 | $3.73 | $18,632 | View SEC filing | |
| 2023-05-18 | BEN-MAIMON CAROLE President and CEO | Purchase | +5,000 | +1.91%266,829 | $3.71 | $18,525 | View SEC filing | |
| 2023-05-18 | Truitt Joseph Director | Purchase | +2,750 | +100.00%2,750 | $3.73 | $10,258 | View SEC filing | |
| 2022-09-20 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) Director, 10% Owner, Other | Purchase | +11,111,108 | +190.58%16,941,357 | $3.15 | $34,999,990 | View SEC filing | |
| 2022-09-20 | Hamilton Thomas Edward Director | Purchase | +317,460 | +166.97%507,590 | $3.15 | $999,999 | View SEC filing | |
| 2022-09-19 | Celano Michael Chief Financial Officer | Purchase | +31,746 | +100.00%31,746 | $3.15 | $100,000 | View SEC filing | |
| 2022-09-19 | BEN-MAIMON CAROLE President and CEO | Purchase | +31,746 | +126.56%56,829 | $3.15 | $100,000 | View SEC filing | |
| 2021-07-02 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) Director, 10% Owner, Other | Purchase | +685,710 | +13.33%5,830,249 | $8.75 | $5,999,963 | View SEC filing | |
| 2021-07-02 | Hamilton Thomas Edward Director | Purchase | +56,710 | +42.50%190,130 | $8.75 | $496,213 | View SEC filing | |
| 2018-06-29 | Hughes Thomas E. See Remarks | Sale | -32,000 | -20.35%125,247 | $10.00 | $320,000 | View SEC filing | |
| 2018-03-09 | Hughes Thomas E. See Remarks | Sale | -5,000 | -3.08%157,247 | $10.00 | $50,000 | View SEC filing | |
| 2017-10-17 | Heller Frances K Director | Purchase | +10,000 | +26.34%47,961 | $3.90 | $38,988 | View SEC filing | |
| 2017-07-12 | KIM DENNIS D Chief Medical Officer | Purchase | +10,000 | +87.39%21,443 | $3.39 | $33,900 | View SEC filing | |
| 2017-05-11 | KIM DENNIS D Chief Medical Officer | Purchase | +10,000 | +693.00%11,443 | $4.40 | $44,000 | View SEC filing | |
| 2016-12-20 | Heller Frances K Director | Purchase | +10,000 | +50.00%30,000 | $3.23 | $32,290 | View SEC filing | |
| 2016-11-17 | Heller Frances K Director | Purchase | +10,000 | +100.00%20,000 | $3.54 | $35,434 | View SEC filing |
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