| Filing Date | Insider | Type | 10b5-1 | Net Shares | Ownership change | Avg. Price | Value | Filing |
|---|---|---|---|---|---|---|---|---|
| 2026-05-22 | Goin Kathleen Chief Operating Officer | Sale | -4,302 | -100.00%0 | $110.56 | $475,631 | View SEC filing | |
| 2026-04-17 | Goin Kathleen Chief Operating Officer | Sale | -4,302 | -100.00%0 | $127.24 | $547,399 | View SEC filing | |
| 2026-04-01 | JENKINS GEORGE M Director | Purchase | +445 | +0.24%187,616 | $112.30 | $49,974 | View SEC filing | |
| 2026-03-20 | Goin Kathleen Chief Operating Officer | Sale | -4,302 | -100.00%0 | $117.99 | $507,611 | View SEC filing | |
| 2026-03-02 | JENKINS GEORGE M Director | Purchase | +4,000 | +2.18%187,171 | $125.00 | $500,000 | View SEC filing | |
| 2026-03-02 | HERON ELAINE J Director | Purchase | +2,400 | +5.28%47,812 | $125.00 | $300,000 | View SEC filing | |
| 2026-02-20 | Goin Kathleen Chief Operating Officer | Sale | -4,302 | -100.00%0 | $79.40 | $341,564 | View SEC filing | |
| 2026-01-23 | Goin Kathleen Chief Operating Officer | Sale | -4,302 | -100.00%0 | $97.63 | $419,983 | View SEC filing | |
| 2025-12-19 | Goin Kathleen Chief Operating Officer | Sale | -4,302 | -100.00%0 | $96.47 | $415,023 | View SEC filing | |
| 2025-11-21 | Goin Kathleen Chief Operating Officer | Sale | -4,302 | -100.00%0 | $86.23 | $370,965 | View SEC filing | |
| 2025-04-10 | JENKINS GEORGE M Director | Purchase | +4,990 | +2.60%196,687 | $20.20 | $100,797 | View SEC filing | |
| 2024-12-19 | JENKINS GEORGE M Director | Purchase | +4,000 | +2.26%180,671 | $12.93 | $51,720 | View SEC filing | |
| 2024-10-28 | GERAGHTY JAMES A Director | Purchase | +1 | +100.00%1 | $1.00 | $1 | View SEC filing | |
| 2024-08-12 | ADAR1 Partners, LP 10% Owner | Purchase | +6,000 | +4.33%144,641 | $15.39 | $92,326 | View SEC filing | |
| 2023-05-30 | KIRITSY CHRISTOPHER P Director | Purchase | +10,000 | +100.00%20,000 | $0.85 | $8,500 | View SEC filing | |
| 2022-05-16 | Demuth Tim Chief Medical Officer | Purchase | +6,000 | +100.00%6,000 | $1.71 | $10,260 | View SEC filing | |
| 2021-09-01 | Olwill Shane Chief Development Officer | Sale | -38,400 | -89.22%4,638 | $5.11 | $196,380 | View SEC filing | |
| 2020-07-22 | Aquilo Capital Management, LLC 10% Owner | Sale | -1,900,000 | -34.08%3,675,530 | $2.95 | $5,605,000 | View SEC filing | |
| 2019-09-10 | BIOTECHNOLOGY VALUE FUND L P Other | Sale | -50,000 | -86.96%314,139 | $4.50 | $224,970 | View SEC filing | |
| 2018-09-17 | KIRITSY CHRISTOPHER P Director | Purchase | +5,000 | +100.00%10,000 | $5.11 | $25,525 | View SEC filing | |
| 2018-05-16 | GERAGHTY JAMES A Director | Purchase | +10,000 | +100.00%20,000 | $5.75 | $57,500 | View SEC filing | |
| 2018-05-02 | ORBIMED ADVISORS LLC 10% Owner, Other | Sale | -1,000,000 | -99.29%38,870 | $6.35 | $6,350,000 | View SEC filing | |
| 2018-02-15 | ORBIMED ADVISORS LLC 10% Owner | Sale | -7,897 | -99.11%49,270 | $8.98 | $70,915 | View SEC filing | |
| 2018-01-04 | ISALY SAMUEL D 10% Owner | Sale | -1,709,620 | -99.32%49,270 | $7.35 | $12,565,707 | View SEC filing | |
| 2017-12-20 | ISALY SAMUEL D 10% Owner | Sale | -147,635 | -99.11%65,398 | $5.70 | $841,520 | View SEC filing |
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