| Filing Date | Insider | Type | 10b5-1 | Net Shares | Ownership change | Avg. Price | Value | Filing |
|---|---|---|---|---|---|---|---|---|
| 2026-06-09 | Bozic Carmen EVP and CMO | Sale | -1,745 | -7.67%21,015 | $450.00 | $785,250 | View SEC filing | |
| 2026-06-03 | Liu Joy EVP and Chief Legal Officer | Sale | -828 | -3.98%19,959 | $439.91 | $364,245 | View SEC filing | |
| 2026-06-02 | Bozic Carmen EVP and CMO | Sale | -1,974 | -7.98%22,760 | $450.00 | $888,300 | View SEC filing | |
| 2026-05-19 | Bunnage Mark E. EVP, Chief Scientific Officer | Sale | -33 | -0.45%7,284 | $453.45 | $14,964 | View SEC filing | |
| 2026-05-19 | Bozic Carmen EVP and CMO | Sale | -1,354 | -5.19%24,734 | $453.45 | $613,971 | View SEC filing | |
| 2026-05-14 | Bozic Carmen EVP and CMO | Sale | -6,988 | -21.13%26,088 | $450.00 | $3,144,600 | View SEC filing | |
| 2026-05-05 | Liu Joy EVP and Chief Legal Officer | Sale | -1,104 | -5.06%20,729 | $425.02 | $469,222 | View SEC filing | |
| 2026-05-05 | Bhatia Sangeeta N. Director | Sale | -318 | -6.07%4,924 | $423.73 | $134,746 | View SEC filing | |
| 2026-04-03 | Liu Joy EVP and Chief Legal Officer | Sale | -978 | -4.29%21,833 | $449.17 | $439,288 | View SEC filing | |
| 2026-03-31 | Bozic Carmen EVP and CMO | Sale | -2,329 | -6.58%33,076 | $450.95 | $1,050,263 | View SEC filing | |
| 2026-03-17 | Bozic Carmen EVP and CMO | Sale | -2,329 | -6.17%35,405 | $481.79 | $1,122,089 | View SEC filing | |
| 2026-03-13 | McKechnie Duncan EVP, Chief Commercial Officer | Sale | -2,633 | -17.41%12,489 | $498.42 | $1,312,340 | View SEC filing | |
| 2026-03-06 | McKechnie Duncan EVP, Chief Commercial Officer | Sale | -2,437 | -13.88%15,122 | $475.30 | $1,158,306 | View SEC filing | |
| 2026-03-04 | Liu Joy EVP and Chief Legal Officer | Sale | -892 | -3.76%22,811 | $495.96 | $442,396 | View SEC filing | |
| 2026-03-03 | Kewalramani Reshma CEO & President | Sale | -40,000 | -28.93%98,278 | $493.47 | $19,738,855 | View SEC filing | |
| 2026-03-03 | Bozic Carmen EVP and CMO | Sale | -2,329 | -5.81%37,734 | $480.31 | $1,118,642 | View SEC filing | |
| 2026-03-02 | Ambrose Kristen SVP & Chief Accounting Officer | Sale | -357 | -5.11%6,624 | $483.36 | $172,560 | View SEC filing | |
| 2026-02-26 | Tatsis Ourania EVP, Chief Reg. & Quality Off. | Sale | -260 | -0.55%46,763 | $486.35 | $126,451 | View SEC filing | |
| 2026-02-26 | Sachdev Amit EVP Chief Patient & Ext Af Off | Sale | -1,846 | -3.22%55,570 | $486.35 | $897,802 | View SEC filing | |
| 2026-02-26 | McKechnie Duncan EVP, Chief Commercial Officer | Sale | -4,910 | -21.85%17,559 | $487.65 | $2,394,365 | View SEC filing | |
| 2026-02-26 | Bunnage Mark E. EVP, Chief Scientific Officer | Sale | -620 | -7.84%7,284 | $486.35 | $301,537 | View SEC filing | |
| 2026-02-26 | Biller Jonathan EVP and Chief Legal Officer | Sale | -945 | -6.47%13,659 | $486.35 | $459,601 | View SEC filing | |
| 2026-02-26 | Atkinson Edward Morrow III EVP, Chief Technical Ops. Off. | Sale | -668 | -3.50%18,432 | $486.35 | $324,882 | View SEC filing | |
| 2026-02-26 | Ambrose Kristen SVP & Chief Accounting Officer | Sale | -223 | -3.10%6,981 | $486.35 | $108,456 | View SEC filing | |
| 2026-02-23 | Sachdev Amit EVP Chief Patient & Ext Af Off | Sale | -58,613 | -49.86%58,934 | $468.83 | $27,479,583 | View SEC filing |
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